Abstract | BACKGROUND:
Mechanical ventilation (MV) is a life-saving intervention in acute respiratory failure without any alternative. However, even protective ventilation strategies applying minimal mechanical stress may evoke ventilator-induced lung injury (VILI). Adjuvant pharmacological strategies in addition to lung-protective ventilation to attenuate VILI are lacking. Adrenomedullin exhibited endothelial barrier-stabilising properties in vitro and in vivo. METHODS: In untreated mice (female C57/Bl6 mice, 11-15 weeks old) and animals treated with adrenomedullin, lung permeability, local and systemic inflammation and markers of distal organ function were assessed following 2 or 6 h of mechanical ventilation with 100% oxygen and protective or moderately injurious ventilator settings, respectively. RESULTS: CONCLUSION: Adjuvant treatment with adrenomedullin may be a promising new pharmacological approach to attenuate VILI.
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Authors | Holger Christian Müller, Martin Witzenrath, Thomas Tschernig, Birgitt Gutbier, Stefan Hippenstiel, Ansgar Santel, Norbert Suttorp, Simone Rosseau |
Journal | Thorax
(Thorax)
Vol. 65
Issue 12
Pg. 1077-84
(Dec 2010)
ISSN: 1468-3296 [Electronic] England |
PMID | 20971983
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bronchodilator Agents
- Cytokines
- Adrenomedullin
- Lactic Acid
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Topics |
- Adrenomedullin
(therapeutic use)
- Animals
- Bronchodilator Agents
(therapeutic use)
- Capillary Permeability
(drug effects)
- Cytokines
(biosynthesis)
- Drug Evaluation, Preclinical
(methods)
- Female
- Kidney Diseases
(prevention & control)
- Lactic Acid
(blood)
- Leukocyte Count
- Lung
(blood supply)
- Mice
- Mice, Inbred C57BL
- Oxygen Consumption
(drug effects)
- Phosphorylation
(drug effects)
- Pulmonary Alveoli
(pathology)
- Respiration, Artificial
(adverse effects, methods)
- Ventilator-Induced Lung Injury
(physiopathology, prevention & control)
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