Abstract | AIM: We conducted a retrospective non-interventional cohort study to analyze the impact of proton pump inhibitors co-administration on methotrexate elimination in cancer patients receiving treatment protocol with the antifolate at high dose (>1 g/m(2) intravenously). PATIENTS AND METHODS: Between 2005 and 2008, 79 patients (mean age: 48.8 years; range: 16-76 years) were treated by high dose methotrexate for 197 cycles. RESULTS: Delayed methotrexate elimination (i.e., plasma concentration >15 μmol/l at 24 h, >1.5 μmol/l at 48 h and/or >0.15 μmol/l at 72 h) occurred in 16% (32/197) of the cycles. The co-prescription of a proton pump inhibitor ( pantoprazole, lansoprazole, omeprazole, esomeprazole) was found in 53% (17/32) of the courses with delayed elimination and in 15% (24/165) of the cycles without delayed elimination. We identified co-administration of proton pump inhibitors as a major risk factor for delayed elimination (odds ratio 6.66, 95% confidence interval 3.13, 14.17). CONCLUSION:
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Authors | R Santucci, D Levêque, A Lescoute, V Kemmel, R Herbrecht |
Journal | Anticancer research
(Anticancer Res)
Vol. 30
Issue 9
Pg. 3807-10
(Sep 2010)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 20944174
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Proton Pump Inhibitors
- Methotrexate
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage, metabolism)
- Drug Interactions
- Humans
- Methotrexate
(administration & dosage, metabolism)
- Middle Aged
- Neoplasms
(drug therapy)
- Proton Pump Inhibitors
(administration & dosage)
- Retrospective Studies
- Young Adult
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