Abstract |
The two-compound ointment ( Taclonex/ Daivobet/ Dovobet ointment) combining calcipotriene 50 microg/g and betamethasone 0.5 mg/g (as dipropionate) is very effective in the treatment of psoriasis vulgaris. There is a possibility that hypothalamo-pituitary-axis (HPA) suppression may occur if the potent corticosteroid component is absorbed to a sufficient extent. The effect of the two-compound ointment on HPA axis function was assessed in two studies. Study 1 was a four-week, double-blind study which compared the effects of the two-compound ointment with betamethasone 0.5 mg/g (as dipropionate; Diprosone) ointment in 24 patients with extensive psoriasis (involving 15-30% of the body surface area). No patients receiving the two-compound ointment had HPA axis suppression. Study 2 assessed HPA axis function after four and 52 weeks in a subset of patients (n = 19) participating in a long-term safety study. Patients were treated with the two-compound ointment for the first four weeks followed by 48 weeks of treatment as needed with either 1) two-compound ointment; 2) two-compound ointment alternating with calcipotriene four-weekly or 3) calcipotriene. No patients using the two-compound ointment for all 52 weeks or alternating four-weekly with calcipotriene had HPA axis suppression.
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Authors | Colin Fleming, Cecilia Ganslandt, Graham P Leese |
Journal | Journal of drugs in dermatology : JDD
(J Drugs Dermatol)
Vol. 9
Issue 8
Pg. 969-74
(Aug 2010)
ISSN: 1545-9616 [Print] United States |
PMID | 20684147
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Dermatologic Agents
- Drug Combinations
- Ointments
- betamethasone dipropionate, calcipotriol drug combination
- Betamethasone
- Calcitriol
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Topics |
- Administration, Cutaneous
- Adult
- Aged
- Betamethasone
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Calcitriol
(administration & dosage, adverse effects, analogs & derivatives, therapeutic use)
- Dermatologic Agents
(administration & dosage, adverse effects, therapeutic use)
- Double-Blind Method
- Drug Combinations
- Female
- Humans
- Hypothalamo-Hypophyseal System
(drug effects)
- Male
- Middle Aged
- Ointments
- Pituitary-Adrenal System
(drug effects)
- Prospective Studies
- Psoriasis
(drug therapy, physiopathology)
- Time Factors
- Young Adult
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