Nutrient dietary patterns and the risk of colorectal cancer: a case-control study from Italy.

Abstract

OBJECTIVE:

The role of diet on colorectal cancer has been considered in terms of single foods and nutrients, but less frequently in terms of dietary patterns.

METHODS:

Data were derived from an Italian case-control study, including 1,225 subjects with cancer of the colon, 728 subjects with rectal cancer, and 4,154 hospital controls. We identified dietary patterns on a selected set of nutrients through principal component factor analysis. Odds ratios (OR) and 95% confidence intervals for both cancers were estimated using unconditional multiple logistic regression.

RESULTS:

We identified 5 major dietary patterns. Direct associations were observed between the Starch-rich pattern and both cancer of the colon (OR = 1.68) and of the rectum (OR = 1.74). Inverse relationships were found between the Vitamins and fiber pattern and rectal cancer (OR = 0.61), between the Unsaturated fats (animal source) and the Unsaturated fats (vegetable source) and cancer of the colon (OR = 0.80 and OR = 0.79, respectively). No other significant association was found.

CONCLUSIONS:

The Starch-rich pattern is potentially an unfavorable indicator of risk for both colon and rectal cancer, whereas the Vitamins and fiber pattern is associated with a reduced risk of rectal cancer and the Unsaturated fats patterns with a reduced risk of colon cancer.

• Authors: Francesca Bravi, Valeria Edefonti, Cristina Bosetti, Renato Talamini, Maurizio Montella, Attilio Giacosa, Silvia Franceschi, Eva Negri, Monica Ferraroni, Carlo La Vecchia, Adriano Decarli
• Journal: Cancer causes & control : CCC (Cancer Causes Control) Vol. 21 Issue 11 Pg. 1911-8 (Nov 2010) ISSN: 1573-7225 [Electronic] Netherlands
• PMID: 20680437 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Dietary Fiber
• Vitamins
• Starch

Topics

• Case-Control Studies
• Colonic Neoplasms (epidemiology, etiology)
• Colorectal Neoplasms (epidemiology, etiology)
• Diet
• Dietary Fiber
• Female
• Food
• Humans
• Incidence
• Italy (epidemiology)
• Logistic Models
• Male
• Middle Aged
• Multicenter Studies as Topic
• Odds Ratio
• Principal Component Analysis
• Rectal Neoplasms (epidemiology, etiology)
• Risk
• Starch
• Vegetables
• Vitamins