Risk factors for depression after kidney transplantation.

Abstract

OBJECTIVE:

Kidney transplantation is recognized as the only potentially curative treatment for end-stage renal failure. But many psychiatric problems are associated with the procedure. The purpose of this study was to identify predictors of a risk for depression after kidney transplantation.

MATERIALS AND METHODS:

This retrospective cohort study recruited 116 first kidney-only Japanese recipients whose mean age was 50.2 +/- 11.87 years include a male/female ratio of 63/53. They underwent transplantation between 1990 and 2008. At enrollment, we used the Zung Self-rating Depression Scale score as well as characterized demographic and clinical features of recipients and donors. Comparisons between depressed and non-depressed patients concerning sociodemographic and clinical characteristics were used chi(2) tests for categorical variables and Student's t-tests for continuous variables. Risk factors with significant correlation coefficients (P < .05) were entered into a stepwise logistic regression model to identify the best single risk factor for depression after kidney transplantation.

RESULT:

The prevalence of depression in this study was 41.4%. Depressed patients were significantly more likely to not have regular incomes, nor to have desired kidney transplantation, to have experienced a rejection episode, and to live alone (P < .05). The single best predictor of future depression was living alone; subjects living alone were 2.51 times more likely to be depressed as those living with others (adjusted odds ratio [OR], 2.51; 95% confidence interval [CI], 1.31-5.22; P < .05).

CONCLUSION:

Although depression after kidney transplantation is driven by multiple, complex, and often overlapping risk factors, we observed characteristic features of recipients including their social environment and follow-up treatment.

• Authors: T Tsunoda, R Yamashita, Y Kojima, S Takahara
• Journal: Transplantation proceedings (Transplant Proc) Vol. 42 Issue 5 Pg. 1679-81 (Jun 2010) ISSN: 1873-2623 [Electronic] United States
• PMID: 20620499 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Attitude to Health
• Cohort Studies
• Depression (classification, epidemiology, etiology)
• Female
• Graft Rejection (epidemiology)
• Humans
• Kidney Failure, Chronic (surgery)
• Kidney Transplantation (adverse effects, psychology)
• Length of Stay
• Life Style
• Living Donors (statistics & numerical data)
• Male
• Middle Aged
• Poverty
• Retrospective Studies
• Risk Factors
• Tissue Donors (statistics & numerical data)