[Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis].

Abstract

Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.

• Authors: Sena Hwang, Do Young Kim, Minju Kim, Young Eun Chon, Hyun Jung Lee, Young-Nyun Park, Jun Yong Park, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon
• Journal: The Korean journal of hepatology (Korean J Hepatol) Vol. 16 Issue 2 Pg. 176-81 (Jun 2010) ISSN: 1738-222X [Print] Korea (South)
• PMID: 20606502 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Humans
• Hypertension, Portal (complications, diagnosis, pathology)
• Male
• Portal Vein
• Protein C Deficiency (complications)
• Protein S Deficiency (complications)
• Tomography, X-Ray Computed
• Venous Thrombosis (complications, diagnosis, pathology)
• Young Adult