In vitro performance assessment of new brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements.

Abstract

The present study investigated the in vitro performance of brushite-forming Zn- and ZnSr-substituted beta-TCP bone cements in terms of wet mechanical strength and biological response. Quantitative phase analysis and structural refinement of the powdered samples were performed by X-ray powder diffraction and Rietveld refinement technique. Initial and final setting times of the cement pastes, measured using Gilmore needles technique, showed that ZnSrCPC sets faster than ZnCPC. The measured values of the wet strength after 48 h of immersion in PBS solution at 37 degrees C showed that ZnSrCPC cements are stronger than ZnCPC cements. Human osteosarcoma-derived MG63 cell line proved the nontoxicity of the cement powders, using the resazurin metabolic assay.

• Authors: S Pina, S I Vieira, P M C Torres, F Goetz-Neunhoeffer, J Neubauer, O A B da Cruz E Silva, E F da Cruz E Silva, J M F Ferreira
• Journal: Journal of biomedical materials research. Part B, Applied biomaterials (J Biomed Mater Res B Appl Biomater) Vol. 94 Issue 2 Pg. 414-420 (Aug 2010) ISSN: 1552-4981 [Electronic] United States
• PMID: 20574977 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bone Cements
• Calcium Phosphates
• beta-tricalcium phosphate
• Zinc
• calcium phosphate, dibasic, dihydrate
• Strontium

Topics

• Bone Cements (chemistry, toxicity)
• Calcium Phosphates (chemistry)
• Cell Line, Tumor
• Humans
• Materials Testing
• Osteosarcoma (pathology)
• Strontium
• Toxicity Tests
• Zinc