Prostate cancer risk in relation to insulin-like growth factor (IGF)-I and IGF-binding protein-3: A nested case-control study in large scale cohort study in Japan.

Abstract

High levels of insulin-like growth factor (IGF)-I are reported to be associated with an increased risk of prostate cancer. On the other hand, the insulin-like growth factor binding protein-3 (IGFBP-3) may decrease the risk. We therefore investigated the influence of serum IGF-I and IGFBP-3 on prostate cancer risk in a case-control study nested within a large-scale cohort in Japan (the Japan Collaborative Cohort Study). Information on lifestyle and sera of the subjects were collected in 1988-90. Serum IGF-I, IGF-II and IGFBP-3 were measured in sera stored at -80 degrees C by immuno-radiometric assay. In 13,508 male subjects of the cohort who donated sera, 40 cases and 120 controls (1:3 matched with age and survey area) were identified. Ages of the cases ranged from 59 to 79 years, with a mean of 69.8. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for the highest and middle tertiles compared with the lowest in controls using a conditional logistic model. Non-adjusted ORs for the highest tertiles were 0.99 (95% CI, 0.34-2.91) for IGF-I (trend-P = 0.60), 1.91 (95% CI, 0.68-5.38) for IGFBP-3 (trend-P = 0.23), 1.73 (95% CI, 0.69-3.47) for IGF-II (trend-P = 0.23), and 0.67 (95% CI, 0.26-1.76) for the IGF-I/IGBP-3 ratio (trend-P = 0.83). Serum levels of IGF-I, IGF-II, IGFBP-3, or IGF-I/IGFBP-3 ratio were thus not thought to be associated with risk of prostate cancer.

• Authors: Kazuya Mikami, Kotaro Ozasa, Masahiro Nakao, Tsuneharu Miki, Kyohei Hayashi, Yoshiyuki Watanabe, Mitsuru Mori, Fumio Sakauchi, Masakazu Washio, Tatsuhiko Kubo, Koji Suzuki, Kenji Wakai, Kei Nakachi, Kazuo Tajima, Yoshinori Ito, Yutaka Inaba, Akiko Tamakoshi, JACC Study Group
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 10 Suppl Pg. 57-61 (Dec 2009) ISSN: 2476-762X [Electronic] Thailand
• PMID: 20553083 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor I
• Insulin-Like Growth Factor II

Topics

• Adult
• Aged
• Biomarkers (blood)
• Case-Control Studies
• Cohort Studies
• Follow-Up Studies
• Humans
• Insulin-Like Growth Factor Binding Protein 3 (blood)
• Insulin-Like Growth Factor I (metabolism)
• Insulin-Like Growth Factor II (metabolism)
• Japan (epidemiology)
• Male
• Middle Aged
• Odds Ratio
• Prognosis
• Prostatic Neoplasms (blood, epidemiology, mortality)
• Risk Factors
• Survival Rate