Abstract | BACKGROUND AND AIM: METHODS: We report a retrospective, observational, single-center case series of 12 consecutively enrolled patients with ulcerative colitis refractory to tacrolimus that received infliximab therapy for the induction of remission. Eight patients received a single infusion of infliximab, and four received two or more infusions. Median follow-up duration was 16.0 months (range, 1.6-41.4 months). The clinical response was evaluated based on a modified Truelove-Witts severity index. RESULTS: Six patients (50.0%) achieved clinical remission within 30 days. Overall cumulative colectomy-free survival was estimated to be 58.3% at 41.4 months. Adverse events included an elevation of liver enzymes (1/12; 8.3%) and a mild infusion reaction (1/12; 8.3%). No mortality occurred. CONCLUSIONS:
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Authors | Shuji Yamamoto, Hiroshi Nakase, Minoru Matsuura, Yusuke Honzawa, Satohiro Masuda, Ken-ichi Inui, Tsutomu Chiba |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 25
Issue 5
Pg. 886-91
(May 2010)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 20546441
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents
- Antibodies, Monoclonal
- Gastrointestinal Agents
- Immunosuppressive Agents
- Infliximab
- Tacrolimus
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Topics |
- Adolescent
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Aged
- Anti-Inflammatory Agents
(administration & dosage, adverse effects, therapeutic use)
- Antibodies, Monoclonal
(administration & dosage, adverse effects, therapeutic use)
- Colectomy
- Colitis, Ulcerative
(diagnosis, drug therapy, surgery)
- Drug Resistance
- Female
- Gastrointestinal Agents
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Infliximab
- Infusions, Intravenous
- Japan
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Remission Induction
- Retrospective Studies
- Severity of Illness Index
- Tacrolimus
(therapeutic use)
- Time Factors
- Treatment Outcome
- Young Adult
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