Genetic and functional study of the IPO5 gene in schizophrenia.

Abstract

The present work reported on a weak association of the importin 5 (IPO5) gene with schizophrenia in combined family and case-control samples and also investigated a possible mechanism by which the IPO5 gene may contribute to the development of the disease in a Chinese population. Our results suggest that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia.

• Authors: Zhen-Qi Wang, Yang Liu, Ning Wu, Qi Xu, Shun-Zi Jin, Gui-Zhi Ju, Lin Ye, Li-Bo Liu, Xuan Zhang, Jiang Wu
• Journal: Psychiatry research (Psychiatry Res) Vol. 187 Issue 3 Pg. 460-1 (May 30 2011) ISSN: 0165-1781 [Print] Ireland
• PMID: 20542336 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• IPO5 protein, human
• beta Karyopherins

Topics

• Adult
• China
• Family Health
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Genotype
• Humans
• Male
• Polymorphism, Single Nucleotide (genetics)
• Schizophrenia (genetics)
• beta Karyopherins (genetics)