The potential value of Clostridium difficile vaccine: an economic computer simulation model.

Abstract

Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease.

• Authors: Bruce Y Lee, Michael J Popovich, Ye Tian, Rachel R Bailey, Paul J Ufberg, Ann E Wiringa, Robert R Muder
• Journal: Vaccine (Vaccine) Vol. 28 Issue 32 Pg. 5245-53 (Jul 19 2010) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 20541582 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: (c) 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Bacterial Vaccines

Topics

• Bacterial Vaccines (administration & dosage, economics)
• Clostridioides difficile
• Computer Simulation
• Cost-Benefit Analysis
• Enterocolitis, Pseudomembranous (prevention & control)
• Humans
• Models, Economic
• Monte Carlo Method
• Risk Factors
• Secondary Prevention