Abstract | RATIONALE: OBJECTIVES: We postulate that pathways associated with a prothrombotic potential are up-regulated in SDB. METHODS: Morning and evening plasminogen activator inhibitor-1 (PAI-1), morning fibrinogen, and morning D-dimer were measured in 537 Cleveland Family Study adults. Piecewise multivariable linear mixed models estimated relative mean change or mean change in the biomarker per 5-unit increase in apnea-hypopnea index (AHI) in two groups: AHI less than 15 and AHI greater than or equal to 15, and hypoxia defined as percentage of sleep time with Sa(O(2)) less than 90% (< 2%, ≥ 2%). MEASUREMENTS AND MAIN RESULTS: Nonlinear associations were demonstrated: morning and evening PAI-1 increased by 12% (95% confidence interval [CI], 5-20%; P < 0.001) and 11% (95% CI, 2-20%; P = 0.01), respectively per 5-unit AHI increase until an AHI of 15, when no further increase in PAI-1 was demonstrated. The association between AHI and morning PAI-1 remained significant after adjusting for evening PAI-1 level (10%; 95% CI, 3-17%; P < 0.01). Morning fibrinogen increased on average by 8.4 mg/dl (95% CI, 3.12-13.65; P = 0.002) per five-unit AHI increase until an AHI of 15. There was no association between AHI and morning D-dimer. Hypoxia severity was not associated with thrombotic marker levels. CONCLUSIONS:
PAI-1 and fibrinogen levels increase monotonically with AHI at degrees of SDB considered mildly to moderately abnormal, suggesting that even mild SDB levels may increase prothrombotic processes. There may be a plateau in this effect, occurring at levels considered to reflect only moderate SDB severity. These relationships with mild-to-moderate SDB were not observed with D-dimer.
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Authors | Reena Mehra, Fang Xu, Denise C Babineau, Russell P Tracy, Nancy S Jenny, Sanjay R Patel, Susan Redline |
Journal | American journal of respiratory and critical care medicine
(Am J Respir Crit Care Med)
Vol. 182
Issue 6
Pg. 826-33
(Sep 15 2010)
ISSN: 1535-4970 [Electronic] United States |
PMID | 20508215
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Fibrin Fibrinogen Degradation Products
- Plasminogen Activator Inhibitor 1
- fibrin fragment D
- Fibrinogen
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Topics |
- Adult
- Biomarkers
(analysis, blood)
- Cross-Sectional Studies
- Family Health
- Female
- Fibrin Fibrinogen Degradation Products
(analysis)
- Fibrinogen
(analysis)
- Humans
- Linear Models
- Male
- Middle Aged
- Multivariate Analysis
- Ohio
- Plasminogen Activator Inhibitor 1
(blood)
- Risk Factors
- Severity of Illness Index
- Sleep Apnea Syndromes
(blood)
- Thrombosis
(blood)
- Up-Regulation
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