Abstract | PURPOSE OF REVIEW: To analyse the association of systemic allergic hymenoptera sting reactions with mastocytosis and elevated baseline serum tryptase and to discuss diagnosis and treatment in patients with both diseases. RECENT FINDINGS: SUMMARY: In all patients with anaphylaxis following hymenoptera stings, baseline serum tryptase should be determined. A value above 11.4 microg/l is often due to mastocytosis and indicates a high risk of very severe anaphylaxis following re- stings. Venom immunotherapy is safe and effective in this situation.
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Authors | Patrizia Bonadonna, Roberta Zanotti, Ulrich Müller |
Journal | Current opinion in allergy and clinical immunology
(Curr Opin Allergy Clin Immunol)
Vol. 10
Issue 4
Pg. 347-53
(Aug 2010)
ISSN: 1473-6322 [Electronic] United States |
PMID | 20485157
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Allergic Agents
- Arthropod Venoms
- Wasp Venoms
- Tryptases
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Topics |
- Anaphylaxis
(etiology, immunology, prevention & control)
- Animals
- Anti-Allergic Agents
(therapeutic use)
- Arthropod Venoms
(administration & dosage, adverse effects, immunology)
- Desensitization, Immunologic
(methods)
- Humans
- Hymenoptera
(immunology)
- Hypersensitivity, Immediate
(complications, etiology, immunology, therapy)
- Insect Bites and Stings
(immunology)
- Mastocytosis
(complications, diagnosis, immunology, therapy)
- Tryptases
(blood)
- Wasp Venoms
(administration & dosage, adverse effects, immunology)
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