[Pathologically complete response of multiple liver metastases from rectal cancer treated with mFOLFOX6 plus bevacizumab].

Abstract

We report a case of pathologically complete response of multiple liver metastases from rectal cancer after neoadjuvant chemotherapy. The patient was a 74-year-old woman who had advanced rectal cancer with synchronous liver metastases (T4N1M1). Following resection of the primary tumor, she received biweekly mFOLFOX6 plus bevacizumab neoadjuvant chemotherapy. After 5 courses, the liver tumors were markedly reduced in size. Three weeks after the final treatment, she underwent partial hepatectomies. Histologically, no cancer cells were detected in any resected specimens. The postoperative course was uneventful, and she has been well without recurrence for one year at the time of writing. Regimens containing bevacizumab may result in good tumor response. Surgical resection is crucial for proof of pathologically complete response.

• Authors: Masaya Inoue, Keisuke Uehara, Seiji Ishiguro, Hideki Nishio, Tomoki Ebata, Yukihiro Yokoyama, Toshio Kokuryo, Nobuyuki Tsunoda, Tsuyoshi Igami, Gen Sugawara, Masahide Fukaya, Masato Nagino
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 107 Issue 5 Pg. 760-7 (May 2010) ISSN: 0446-6586 [Print] Japan
• PMID: 20460850 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Organoplatinum Compounds
• Bevacizumab
• Leucovorin
• Fluorouracil

Topics

• Adenocarcinoma (pathology)
• Aged
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Bevacizumab
• Female
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Liver Neoplasms (drug therapy, secondary)
• Organoplatinum Compounds (administration & dosage)
• Rectal Neoplasms (pathology)