Abstract | OBJECTIVE: METHODS: Clinical data of 94 corticosteroid treatment and 32 non- corticosteroid treatment IPF patients during 2000 - 2004 were retrospectively analyzed and their survival rates compared between two groups. The corticosteroid treatment patients were divided into 3 groups: improved, steady and worsened group according to the pulmonary function data. Therapeutic effects and survival rates were compared between these 3 groups. RESULTS: In the treatment group, 6 (6.4%) patients could not be located, 22 (23.4%) patients survived, and 66 (70.2%) patients died. In the non- corticosteroid treatment group, 1 (3.1%) patients could not be located, 2 (6.3%) patients survived and 29 (90.6%) patients died. No statistically significant difference existed between the two groups (P > 0.05). Sixty-two corticosteroid treatment patients were followed up for 3-6 months. Among them, 19 (30.7%) patients improved, 11 (17.7%) patients remained steady and 32 (51.6%) patients worsened in pulmonary function. In 19 improved patients, 7 (36.8%) survived and 12 (63.2%) died. In 11 steady patients, 3 (27.2%) survived and 8 (72.7%) died. In 32 worsened patients, 3 (9.4%) could not be located, 1(3.1%) survived and 28 (87.5%) died. The survival rate of the improved and steady groups was higher than that of the worsened group (P < 0.01). CONCLUSIONS: There is some therapeutic effect of corticosteroids in the early alveolitis stage of IPF. The prognosis of the patients with improved and steady pulmonary function parameters during the first 3 - 6 months is better than that of worsened patients.
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Authors | Zhen-hua Li, Shou-Chun Peng, Jian Kang, Xian-ming Hou, Run-jiang Yu |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 90
Issue 12
Pg. 804-7
(Mar 30 2010)
ISSN: 0376-2491 [Print] China |
PMID | 20450617
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Aged
- Female
- Humans
- Idiopathic Pulmonary Fibrosis
(drug therapy, mortality)
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Survival Rate
- Treatment Outcome
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