Abstract | BACKGROUND: Serum asymmetric dimethylarginine (ADMA) levels are increased in maintenance hemodialysis patients, and this abnormality may increase cardiovascular risk. We investigated whether combined administration of oral folate and intravenous methylcobalamin in such patients is more beneficial than oral folate alone at decreasing circulating ADMA levels. STUDY DESIGN: Randomized controlled trial. SETTING & PARTICIPANTS: INTERVENTION: OUTCOMES: PRIMARY OUTCOMES: normalization of plasma homocysteine levels (<15 mumol/L), decrease in serum ADMA levels. SECONDARY OUTCOMES: MEASUREMENTS: Blood samples were collected under fasting conditions during the prehemodialysis procedure. RESULTS: LIMITATIONS: This study had an open-label nature and did not examine long-term effects of homocysteine-normalizing therapy (no clinical end points). CONCLUSION:
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Authors | Katsushi Koyama, Akinori Ito, Jun Yamamoto, Takae Nishio, Junko Kajikuri, Yasuaki Dohi, Nobuyuki Ohte, Akira Sano, Hiroshi Nakamura, Hiromichi Kumagai, Takeo Itoh |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 55
Issue 6
Pg. 1069-78
(Jun 2010)
ISSN: 1523-6838 [Electronic] United States |
PMID | 20430500
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Homocysteine
- Vitamin B Complex
- N,N-dimethylarginine
- Folic Acid
- Arginine
- mecobalamin
- Vitamin B 12
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Topics |
- Administration, Oral
- Aged
- Arginine
(analogs & derivatives, blood)
- Cardiovascular Diseases
(epidemiology)
- Drug Therapy, Combination
- Female
- Folic Acid
(administration & dosage, therapeutic use)
- Homocysteine
(blood)
- Humans
- Hyperhomocysteinemia
(prevention & control)
- Injections, Intravenous
- Kidney Failure, Chronic
(blood, therapy)
- Male
- Middle Aged
- Renal Dialysis
- Risk Factors
- Vitamin B 12
(administration & dosage, analogs & derivatives, therapeutic use)
- Vitamin B Complex
(administration & dosage, therapeutic use)
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