Abstract | BACKGROUND AND PURPOSE: Thrombolytics-induced recanalization fails in a significant portion of patients with ischemic stroke, which is partly due to the resistance of clots to lysis by thrombolytic agents. The pretreatment level of endogenous fibrinolysis inhibitors may affect such thrombolysis failure. METHODS: RESULTS: Arteries were recanalized [Thrombolysis in Myocardial Infarction (TIMI) grade 2 or 3] in 30 patients, but not (TIMI grade 0 or 1) in the other 13. The plasma PAI-1 level was significantly higher in patients without recanalization (nonrecanalization) than in those with recanalization and in normal controls. The TAFI levels did not differ among the groups. CONCLUSIONS: The pretreatment PAI-1 levels are increased in acute stroke patients with thrombolysis failure.
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Authors | Seo Hyun Kim, Sang Won Han, Eun Hee Kim, Dong Joon Kim, Kyung Yul Lee, Dong Ik Kim, Ji Hoe Heo |
Journal | Journal of clinical neurology (Seoul, Korea)
(J Clin Neurol)
Vol. 1
Issue 2
Pg. 142-7
(Oct 2005)
ISSN: 2005-5013 [Electronic] Korea (South) |
PMID | 20396461
(Publication Type: Journal Article)
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