Nuclear translocation of nuclear factor Kappa B in first trimester deciduas and chorionic villi in early spontaneous miscarriage women.

Abstract

The nuclear factor kappa B is widely expressed in the distinct subpopulations of chorionic villi and deciduas of first-trimester pregnancies. We examined the cellular distribution and expression of nuclear factor kappa B in the human first-trimester chorionic villi and deciduas of women with early spontaneous miscarriage and viable pregnancy by confocal laser scanning microscope and immunohistochemistry. There is a greater nuclear translocation of nuclear factor kappa B is restricted to villous stromal cells, decidual stromal cells, glandular epithelial cells and vessel endothelial cells in early spontaneous miscarriage than in viable pregnancies. Collectively these observations suggest that over-activation of nuclear factor kappa B has a relationship with early spontaneous miscarriages.

• Authors: Li-Qin Wang, Xue-Wen Yu, Chun-Fang Yan, Xiang Wang
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 11 Issue 2 Pg. 521-531 (Feb 03 2010) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 20386652 (Publication Type: Journal Article)

Chemical References

• NF-kappa B
• Transcription Factor RelA

Topics

• Abortion, Spontaneous (etiology, metabolism)
• Cell Nucleus (metabolism)
• Chorionic Villi (metabolism)
• Decidua (metabolism)
• Epithelial Cells (metabolism)
• Female
• Humans
• Immunohistochemistry
• Microscopy, Confocal
• NF-kappa B (metabolism)
• Pregnancy
• Pregnancy Trimester, First
• Stromal Cells (metabolism)
• Transcription Factor RelA (metabolism)