Abstract |
Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis.
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Authors | Rohidas B Arote, Mi-Kyong Yoon, Tae-Hee Kim, Dhananjay Jere, Hu-Lin Jiang, You-Kyoung Kim, In-Kyu Park, Chong-Su Cho |
Journal | Journal of nanoscience and nanotechnology
(J Nanosci Nanotechnol)
Vol. 10
Issue 5
Pg. 3294-8
(May 2010)
ISSN: 1533-4880 [Print] United States |
PMID | 20358942
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Macromolecular Substances
- Nanocapsules
- Polyesters
- polycaprolactone
- Folic Acid
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Topics |
- Antineoplastic Agents
(administration & dosage, chemistry)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Folic Acid
(administration & dosage, chemistry)
- Humans
- Lung Neoplasms
(drug therapy, pathology)
- Macromolecular Substances
(chemistry)
- Materials Testing
- Molecular Conformation
- Nanocapsules
(chemistry, ultrastructure)
- Nanomedicine
(methods)
- Polyesters
(chemistry)
- Surface Properties
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