Effectiveness of intra-operative Mitomycin-C in reducing the recurrence of pterygium in Irrua, Nigeria.

Abstract

AIMS AND OBJECTIVES:

To evaluate the effectiveness of intra-operative Mitomycin-C application after pterygium surgery in Irrua, Nigeria.

MATERIALS AND METHODS:

The medical records of all patients who had pterygium excision with intra-operative application of 0.4mg/ml Mitomycin C between June 2002 and May 2007 and followed up for at least a year were reviewed.

RESULTS:

Two hundred and forty three eyes (196 patients) had pterygium excision with intra-operative application of 0.4mg/ml Mitomycin C over this period. Male to female ratio was 2:1. The mean age of the patients was 47.1years (SD+ 15.4) Eleven eyes had recurrence after a minimum follow up period of one year. Six (54.5%) out of the eleven eyes that had recurrence had conjunctival granuloma and in such cases recurrence was early (between 2 to 3 months of surgery). Conjunctival granuloma was the main complication occurring in 35 eyes (14.4%). Occurrence of granuloma was significantly associated with recurrence (P =0.0006). Delayed wound healing occurred in 5 eyes (2.1%). There was no case of either scleral or corneal melting.

CONCLUSION:

Intra-operative application of 0.4mg/ml Mitomycin C is very effective in reduction of recurrence of pterygium after excision. Hence patients should be given the benefit of intra-operative use of Mitomycin C during pterygium surgery.

• Authors: M E Enock, A E Omoti, O A Dawodu, U C Fuh, I E Eguaoje
• Journal: The Nigerian postgraduate medical journal (Niger Postgrad Med J) Vol. 17 Issue 1 Pg. 55-9 (Mar 2010) ISSN: 1117-1936 [Print] Nigeria
• PMID: 20348984 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Alkylating Agents
• Antibiotics, Antineoplastic
• Ophthalmic Solutions
• Mitomycin

Topics

• Adult
• Age Distribution
• Aged
• Aged, 80 and over
• Alkylating Agents (administration & dosage)
• Antibiotics, Antineoplastic (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Ophthalmic Solutions
• Postoperative Complications (prevention & control)
• Pterygium (drug therapy, surgery)
• Recurrence
• Sex Distribution
• Treatment Outcome
• Wound Healing (drug effects)
• Young Adult