Pattern recognition receptors and inflammation.

Abstract

Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors. The intracellular signaling cascades triggered by these PRRs lead to transcriptional expression of inflammatory mediators that coordinate the elimination of pathogens and infected cells. However, aberrant activation of this system leads to immunodeficiency, septic shock, or induction of autoimmunity. In this Review, we discuss the role of PRRs, their signaling pathways, and how they control inflammatory responses.

• Authors: Osamu Takeuchi, Shizuo Akira
• Journal: Cell (Cell) Vol. 140 Issue 6 Pg. 805-20 (Mar 19 2010) ISSN: 1097-4172 [Electronic] United States
• PMID: 20303872 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
• Copyright: 2010 Elsevier Inc. All rights reserved.

Chemical References

• Receptors, Pattern Recognition
• Toll-Like Receptors

Topics

• Animals
• Cytoplasm (genetics)
• Humans
• Infections (immunology)
• Inflammation (immunology)
• Receptors, Pattern Recognition (immunology)
• Toll-Like Receptors (immunology)