Abstract | OBJECTIVES: The literature indicates that cardiovascular drug use is higher during the years prior to diagnosis of type 2 diabetes mellitus. As there are pharmaco-epidemiological and economic consequences of enhanced medication use prior to diagnosis of diabetes, there is a need for a comparative analysis of the drug-use pattern by patients with a subsequent diagnosis of diabetes and control patients. This pilot study aimed to investigate cardiovascular drug use in patients with a subsequent diagnosis of diabetes using data extracted from 200 community pharmacies in the Belgian township of Hasselt. METHODS: Based on community pharmacy data, a retrospective case-control study compared the drug use of patients with a subsequent diagnosis of type 2 diabetes (cases) with patients without a subsequent diagnosis (controls). Cases were identified if patients started taking metformin (and possibly other drugs used in diabetes) during the 2004-2006 study period. Drug use was expressed as a binary variable, reflecting whether or not a patient took drugs belonging to a specific cardiovascular subclass. KEY FINDINGS: Our dataset consisted of 158 cases with a subsequent diagnosis of type 2 diabetes and 632 control patients. Patients with a subsequent diagnosis of type 2 diabetes had a higher propensity to take cardiovascular drugs prior to diagnosis than control patients. This trend was observed across all cardiovascular drug classes, except for calcium-channel blockers, and was statistically significant for beta-blocking agents and agents acting on the renin-angiotensin system. CONCLUSIONS: A positive association was observed between cardiovascular drug use and subsequent diagnosis of type 2 diabetes. This study emphasizes the potential role for community pharmacy in early identification of diabetes using more targeted screening based on cardiovascular drug use as derived from pharmacy databases.
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Authors | Steven Simoens, Sandra De Coster, Marleen Dethier, Jan Lenie, Paul Meuwissen, Gert Laekeman |
Journal | The International journal of pharmacy practice
(Int J Pharm Pract)
Vol. 17
Issue 2
Pg. 127-9
(Apr 2009)
ISSN: 0961-7671 [Print] England |
PMID | 20214262
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Antagonists
- Cardiovascular Agents
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Topics |
- Adrenergic beta-Antagonists
(therapeutic use)
- Aged
- Belgium
- Cardiovascular Agents
(pharmacology, therapeutic use)
- Case-Control Studies
- Community Pharmacy Services
(organization & administration)
- Diabetes Mellitus, Type 2
(diagnosis)
- Female
- Humans
- Male
- Mass Screening
(methods)
- Middle Aged
- Pilot Projects
- Renin-Angiotensin System
(drug effects)
- Retrospective Studies
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