[Concentrations of granulocyte colony-stimulating factor in children with moyamoya disease].

Abstract

OBJECTIVE:

To explore the roles of granulocyte colony-stimulating factor in the pathogenesis of moyamoya disease.

METHODS:

Serum G-CSF concentrations were measured using enzyme linked immunosorbent assay (ELISA) in 20 children with moyamoya disease and 20 healthy children.

RESULTS:

Serum G-CSF concentration (35.7+/-10.3 pg/mL) in children with moyamoya disease was significantly higher than that in healthy controls (23.5+/-3.8 pg/mL) (p<0.01).

CONCLUSIONS:

The elevated serum G-CSF concentration in children with moyamoya disease suggests that G-CSF may play an important role in the pathogenesis of moyamoya disease.

• Authors: Ming-Sheng Ma, Li-Ping Zou, Ying-Xue Ding, Hong Jin
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 12 Issue 2 Pg. 117-9 (Feb 2010) ISSN: 1008-8830 [Print] China
• PMID: 20199726 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Vascular Endothelial Growth Factor A
• Granulocyte Colony-Stimulating Factor

Topics

• Child
• Child, Preschool
• Female
• Granulocyte Colony-Stimulating Factor (blood, physiology)
• Humans
• Male
• Moyamoya Disease (blood, etiology)
• Vascular Endothelial Growth Factor A (analysis, physiology)