Association of lipoprotein-associated phospholipase A2 with coronary artery disease in African-Americans and Caucasians.

Abstract

CONTEXT:

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is bound predominately to low-density lipoprotein and has been implicated as a risk factor for coronary artery disease (CAD).

OBJECTIVE:

We investigated the association between Lp-PLA(2) and CAD in a biethnic African-American and Caucasian population.

DESIGN:

Lp-PLA(2) mass, activity, and index, an integrated measure of mass and activity, and other cardiovascular risk factors were determined in 224 African-Americans and 336 Caucasians undergoing coronary angiography.

MAIN OUTCOME MEASURES:

We assessed the distribution of Lp-PLA(2) levels and determined the predictive role of Lp-PLA(2) as a risk factor for CAD.

RESULTS:

Levels of Lp-PLA(2) mass and activity were higher among Caucasians compared with African-Americans (293 +/- 75 vs. 232 +/- 76 ng/ml, P < 0.001 for mass and 173 +/- 41 vs. 141 +/- 39 nmol/min/ml, P < 0.001 for activity, respectively). However, Lp-PLA(2) index was similar in the two groups (0.61 +/- 0.17 vs. 0.64 +/- 0.19, P = NS). In both ethnic groups, Lp-PLA(2) activity and index was significantly higher among subjects with CAD. African-American subjects with CAD had significantly higher Lp-PLA(2) index than corresponding Caucasian subjects (0.69 +/- 0.20 vs. 0.63 +/- 0.18, P = 0.028). In multivariate regression analyses, after adjusting for other risk factors, Lp-PLA(2) index was independently (odds ratio 6.7, P = 0.047) associated with CAD in African-Americans but not Caucasians.

CONCLUSIONS:

Lp-PLA(2) activity and index was associated with presence of CAD among African-Americans and Caucasians undergoing coronary angiography. The findings suggest an independent impact of vascular inflammation among African-Americans as contributory to CAD risk and underscore the importance of Lp-PLA(2) as a cardiovascular risk factor.

• Authors: Erdembileg Anuurad, Zeynep Ozturk, Byambaa Enkhmaa, Thomas A Pearson, Lars Berglund
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 95 Issue 5 Pg. 2376-83 (May 2010) ISSN: 1945-7197 [Electronic] United States
• PMID: 20194707 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• 1-Alkyl-2-acetylglycerophosphocholine Esterase

Topics

• 1-Alkyl-2-acetylglycerophosphocholine Esterase (blood)
• Black People
• Coronary Angiography
• Coronary Disease (blood, diagnostic imaging)
• Enzyme-Linked Immunosorbent Assay
• Humans
• Insulin Resistance
• Predictive Value of Tests
• Regression Analysis
• Risk Factors
• White People