Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis.

Abstract

BACKGROUND:

Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear.

AIMS:

To determine whether individuals exhibit superior temporal gyral changes before the onset of psychosis.

METHOD:

We used magnetic resonance imaging to examine grey matter volumes of the superior temporal gyrus and its subregions (planum polare, Heschl's gyrus, planum temporale, and rostral and caudal regions) in 97 antipsychotic-naive individuals at ultra-high risk of psychosis, of whom 31 subsequently developed psychosis and 66 did not, and 42 controls.

RESULTS:

Those at risk of psychosis had significantly smaller superior temporal gyri at baseline compared with controls bilaterally, without any prominent subregional effect; however, there was no difference between those who did and did not subsequently develop psychosis.

CONCLUSIONS:

Our findings indicate that grey matter reductions of the superior temporal gyrus are present before psychosis onset, and are not due to medication, but these baseline changes are not predictive of transition to psychosis.

• Authors: Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Mark Walterfang, Lisa J Phillips, Bridget Soulsby, Yasuhiro Kawasaki, Patrick D McGorry, Michio Suzuki, Dennis Velakoulis, Christos Pantelis
• Journal: The British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 196 Issue 3 Pg. 206-11 (Mar 2010) ISSN: 1472-1465 [Electronic] England
• PMID: 20194543 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antipsychotic Agents

Topics

• Adolescent
• Adult
• Affective Disorders, Psychotic (drug therapy, pathology)
• Antipsychotic Agents (therapeutic use)
• Brain Mapping (methods)
• Brief Psychiatric Rating Scale
• Cerebral Cortex (pathology)
• Female
• Functional Laterality
• Humans
• Longitudinal Studies
• Magnetic Resonance Imaging (methods)
• Male
• Predictive Value of Tests
• Risk Factors
• Schizophrenia (drug therapy, pathology)
• Schizophrenic Psychology
• Statistics as Topic
• Temporal Lobe (pathology)
• Young Adult