Abstract | BACKGROUND: METHODS: A total of 183 consecutive firstever ischemic stroke inpatients and 164 non- stroke patients were screened for the length of (GT)(n) repeats in HO-1 promoter. The long (L) and short (S) genotype are defined as the averaged repeat number >26 and <==26, respectively. RESULTS:
Stroke patients tended to have more proportions of hypertension, diabetics and genotype L, than those of genotype S. Patients with genotype L of HO-1 gene promoter have higher stroke risk in comparison with genotype S especially in dyslipidemia individuals. The significant differences on stroke risk in multivariate odds ratios were found especially in people with low HDL-C levels. CONCLUSIONS: Subjects carrying longer (GT)(n) repeats in HO-1 gene promoter may have greater susceptibility to develop cerebral ischemic only in the presence of low HDL-C, suggesting the protective effects in HO-1 genotype S in the process of ischemic stroke, particularly in subjects with poor HDL-C status.
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Authors | Chyi-Huey Bai, Jiunn-Rong Chen, Hou-Chang Chiu, Chia-Chi Chou, Lee-Young Chau, Wen-Harn Pan |
Journal | Journal of biomedical science
(J Biomed Sci)
Vol. 17
Pg. 12
(Feb 23 2010)
ISSN: 1423-0127 [Electronic] England |
PMID | 20175935
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Guanosine
- Heme Oxygenase-1
- Thiamine
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Topics |
- Cholesterol, HDL
(blood, metabolism)
- Dyslipidemias
(complications, genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Guanosine
(chemistry)
- Heme Oxygenase-1
(genetics)
- Humans
- Male
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Risk Factors
- Stroke
(etiology, genetics)
- Thiamine
(chemistry)
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