Abstract | BACKGROUND: STUDY DESIGN: A comprehensive search of the PubMed database for clinical trials and observational studies of dysmenorrhea treatments from 2004 onwards. RESULTS: Eighteen publications were identified. Ten randomized controlled trials (RCTs) assessing NSAIDs for treating primary dysmenorrhea demonstrated superior pain relief compared with placebo, but no superiority was established among different NSAIDS. Two RCTs and six nonrandomized observational or prospective studies assessing the effect of hormonal contraceptives on dysmenorrhea strongly suggest a beneficial effect for dysmenorrheic pain relief and were conducted mainly in larger populations (N=41-6169) than those in the NSAID trials (N=10-337). Ethinylestradiol/chlormadinone acetate was the only formulation that provided a more pronounced relief of dysmenorrheic pain compared with a parallel alternative or previously used hormonal contraceptive. Methodological inconsistencies were widespread between the hormonal contraceptive studies. CONCLUSIONS:
|
Authors | Hans-Peter Zahradnik, Aida Hanjalic-Beck, Klaus Groth |
Journal | Contraception
(Contraception)
Vol. 81
Issue 3
Pg. 185-96
(Mar 2010)
ISSN: 1879-0518 [Electronic] United States |
PMID | 20159173
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Copyright | Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Analgesics
- Anti-Inflammatory Agents, Non-Steroidal
- Contraceptives, Oral, Hormonal
|
Topics |
- Analgesics
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Contraceptives, Oral, Hormonal
(therapeutic use)
- Dysmenorrhea
(drug therapy)
- Female
- Humans
|