Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.

Abstract

Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.

• Authors: An-Shen Lin, E Paige Stout, Jacques Prudhomme, Karine Le Roch, Craig R Fairchild, Scott G Franzblau, William Aalbersberg, Mark E Hay, Julia Kubanek
• Journal: Journal of natural products (J Nat Prod) Vol. 73 Issue 2 Pg. 275-8 (Feb 26 2010) ISSN: 1520-6025 [Electronic] United States
• PMID: 20141173 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antimalarials
• Diterpenes
• Macrolides
• Vancomycin
• Amphotericin B

Topics

• Amphotericin B (pharmacology)
• Antimalarials (chemistry, isolation & purification, pharmacology)
• Candida albicans (drug effects)
• Diterpenes (chemistry, isolation & purification, pharmacology)
• Drug Resistance (drug effects)
• Drug Screening Assays, Antitumor
• Enterococcus faecium (drug effects)
• Female
• Fiji
• Humans
• Macrolides (chemistry, isolation & purification, pharmacology)
• Male
• Methicillin-Resistant Staphylococcus aureus (drug effects)
• Molecular Structure
• Mycobacterium tuberculosis (drug effects)
• Nuclear Magnetic Resonance, Biomolecular
• Plasmodium falciparum (drug effects)
• Rhodophyta (chemistry)
• Vancomycin (pharmacology)