Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris.

Abstract

BACKGROUND:

Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and in patients with severe angina pectoris.

METHODS AND RESULTS:

To further confirm the effectiveness and safety of SW therapy, 8 patients with severe angina pectoris were treated with SW therapy in a double-blind, placebo-controlled and cross-over manner. SW therapy, but not placebo, significantly improved chest pain symptoms and cardiac function without any complications or adverse effects.

CONCLUSIONS:

Extracorporeal cardiac SW therapy is an effective, safe and non-invasive therapeutic option for severe angina pectoris.

• Authors: Yoku Kikuchi, Kenta Ito, Yoshitaka Ito, Takashi Shiroto, Ryuji Tsuburaya, Kentaro Aizawa, Kiyotaka Hao, Yoshihiro Fukumoto, Jun Takahashi, Morihiko Takeda, Masaharu Nakayama, Satoshi Yasuda, Shinichi Kuriyama, Ichiro Tsuji, Hiroaki Shimokawa
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 74 Issue 3 Pg. 589-91 (Mar 2010) ISSN: 1347-4820 [Electronic] Japan
• PMID: 20134096 (Publication Type: Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Placebos

Topics

• Aged
• Aged, 80 and over
• Angina Pectoris (therapy)
• Chest Pain (therapy)
• Cross-Over Studies
• Double-Blind Method
• Female
• Humans
• Lithotripsy (adverse effects, methods)
• Male
• Middle Aged
• Placebos
• Severity of Illness Index
• Treatment Outcome
• Ultrasonic Therapy (adverse effects, methods)