Abstract | AIMS: We have evaluated the therapeutic efficacy and safety of pulse steroid therapy for ulcerative colitis (UC) in a Japanese pediatric population by means of a survey. METHODS: RESULTS: 21 of 62 cases in 6 of 19 centers registered in this study had been treated with pulse steroid therapy. The success rate of remission induction with this treatment was 55%, and improvement was observed in all cases in which remission was not achieved. There were no reports of any obvious side effects. The most common reason for using pulse steroid therapy was for remission induction in relapsed cases. Over the course of 12 (or fewer) months, the number of cases in which remission was maintained was only 1 in 4. However, the amount of concomitant steroid use had significantly decreased after 1 year. CONCLUSIONS: This survey shows that in Japan, pulse steroid therapy is used for a relatively large number of children with UC and is as an effective method of remission induction that has few side effects.
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Authors | Satoru Nagata, Toshiaki Shimizu, Takahiro Kudo, Takeshi Tomomasa, Hitoshi Tajiri, Atsushi Yoden, Seiichi Kagimoto, Takuji Tahara, Kohsuke Ushijima, Keiichi Uchida, Akio Kobayashi |
Journal | Digestion
(Digestion)
Vol. 81
Issue 3
Pg. 188-92
( 2010)
ISSN: 1421-9867 [Electronic] Switzerland |
PMID | 20090334
(Publication Type: Journal Article)
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Copyright | Copyright 2010 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Child
- Colitis, Ulcerative
(drug therapy)
- Dose-Response Relationship, Drug
- Gastroenterology
- Humans
- Inflammatory Bowel Diseases
- Japan
- Pediatrics
- Pulse Therapy, Drug
(statistics & numerical data)
- Recurrence
- Remission Induction
- Societies, Medical
- Steroids
(administration & dosage, adverse effects)
- Surveys and Questionnaires
- Treatment Outcome
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