NCCN Task Force: Transfusion and iron overload in patients with myelodysplastic syndromes.

Abstract

The National Comprehensive Cancer Network (NCCN) convened a multidisciplinary task force to critically review the evidence for iron chelation and the rationale for treatment of transfusional iron overload in patients with myelodysplastic syndromes (MDS). The task force was charged with addressing issues related to tissue iron toxicity; the role of MRI in assessing iron overload; the rationale and role of treating transfusional iron overload in patients with MDS; and the impact of iron overload on bone marrow transplantation. This report summarizes the background data and ensuing discussion from the NCCN Task Force meeting on transfusional iron overload in MDS.

• Authors: Peter L Greenberg, Cynthia K Rigsby, Richard M Stone, H Joachim Deeg, Steven D Gore, Michael M Millenson, Stephen D Nimer, Margaret R O'Donnell, Paul J Shami, Rashmi Kumar
• Journal: Journal of the National Comprehensive Cancer Network : JNCCN (J Natl Compr Canc Netw) Vol. 7 Suppl 9 Pg. S1-16 (Dec 29 2009) ISSN: 1540-1413 [Electronic] United States
• PMID: 20064286 (Publication Type: Journal Article)

Chemical References

• Iron Chelating Agents

Topics

• Advisory Committees
• Chelation Therapy
• Humans
• Iron Chelating Agents (therapeutic use)
• Iron Overload (etiology, pathology, therapy)
• Magnetic Resonance Imaging
• Myelodysplastic Syndromes (drug therapy, therapy)
• Thalassemia
• Transfusion Reaction