[Use of prestarium (perindopril) in patients with polymorbidity syndrome (AH, DM, nephropathy)].

Abstract

The study included 20 patients aged 61-86 (mean 73.1 +/- 3.1) years with stage II hypertensive disease, type 2 diabetes and nephropathy with signs of grade I chronic renal insufficiency (CRI). The major parameters measured were AP, HR, laboratory characteristics of carbohydrate metabolism and renal function. Prestarium given at a dose of 4 mg BID had not only antihypertensive but also negative chronotropic effect, decreased energy consumption by myocardium, and normalized daily AP profile (24 hr AP monitoring). Adequate control of diabetes ensured close-to-normal carbohydrate metabolism. Prestarium therapy did not cause further aggravation of renal insufficiency in patients with grade I CRI, nor did it alter creatinine and urea levels.

• Authors: R M Zaslavskaia, N D Buniatian, S V Sergeev, O A Lednev
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 87 Issue 10 Pg. 61-2 ( 2009) ISSN: 0023-2149 [Print] Russia (Federation)
• PMID: 20017355 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Blood Glucose
• Creatinine
• Perindopril

Topics

• Aged
• Aged, 80 and over
• Angiotensin-Converting Enzyme Inhibitors (administration & dosage, therapeutic use)
• Blood Glucose (metabolism)
• Blood Pressure (drug effects)
• Blood Urea Nitrogen
• Creatinine (blood, urine)
• Diabetes Mellitus, Type 2 (blood, complications, drug therapy)
• Dose-Response Relationship, Drug
• Female
• Follow-Up Studies
• Humans
• Hypertension (complications, drug therapy, physiopathology)
• Male
• Middle Aged
• Perindopril (administration & dosage, therapeutic use)
• Renal Insufficiency (complications, drug therapy, metabolism)
• Treatment Outcome