Abstract | BACKGROUND: METHODS: HER2 status was tested in 33 mucinous carcinomas and 16 mucinous borderline ovarian tumors (BOT)). Five cases with documented recurrence and with tissue from the recurrence available for testing were analyzed to determine whether HER2 amplification status changed over time. Three prospectively identified recurrent mucinous ovarian carcinomas were assessed for HER2 amplification and patients received trastuzumab therapy with conventional chemotherapy. RESULTS: Amplification of HER2 was observed in 6/33 (18.2%) mucinous carcinomas and 3/16 (18.8%) BOT. HER2 amplification in primary mucinous carcinomas was not associated with an increased likelihood of recurrence. The prospectively identified recurrent mucinous carcinomas showed overexpression and amplification of HER2; one patient's tumor responded dramatically to trastuzumab in combination with conventional chemotherapy, while another patient experienced an isolated central nervous system recurrence after trastuzumab therapy. CONCLUSION:
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Authors | Jessica N McAlpine, Kimberly C Wiegand, Russell Vang, Bridgett M Ronnett, Anna Adamiak, Martin Köbel, Steve E Kalloger, Kenneth D Swenerton, David G Huntsman, C Blake Gilks, Dianne M Miller |
Journal | BMC cancer
(BMC Cancer)
Vol. 9
Pg. 433
(Dec 10 2009)
ISSN: 1471-2407 [Electronic] England |
PMID | 20003286
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antineoplastic Agents
- Trastuzumab
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Topics |
- Adenocarcinoma, Mucinous
(classification, drug therapy, genetics, mortality)
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal
(administration & dosage, therapeutic use)
- Antibodies, Monoclonal, Humanized
- Antineoplastic Agents
(therapeutic use)
- Drug Delivery Systems
- Female
- Gene Amplification
(physiology)
- Gene Expression Regulation, Neoplastic
- Genes, erbB-2
- Humans
- Middle Aged
- Ovarian Neoplasms
(classification, drug therapy, genetics, mortality)
- Recurrence
- Retrospective Studies
- Trastuzumab
- Up-Regulation
- Young Adult
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