Abstract | BACKGROUND: AIM: To assess the relationship between severity of liver injury and CV risk markers in a large, well-characterized group of patients with biopsy-proven NAFLD. METHODS: RESULTS: All lipid ratios were found to be significantly associated with NAFLD (p<0.05) after adjusting for age and gender. More importantly, there was a stepwise, statistically significant increase in lipid ratios from patients with normal biopsies to patients with simple steatosis to those with NASH (p<0.05). A positive correlation was found between the lipid ratios and NAFLD activity score ( NAS) as well as the individual histological features of the NAS (steatosis, inflammation, and ballooning) with the strongest correlation being with NAS (rho (95% CI) 0.41 (0.21, 0.62), p<0.001). CONCLUSION: In patients with NAFLD, the histologic severity of liver injury and inflammation is strongly associated with an increased CV risk and an atherogenic lipid profile.
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Authors | Naim Alkhouri, Tarek Abu-Rajab Tamimi, Lisa Yerian, Rocio Lopez, Nizar N Zein, Ariel E Feldstein |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 55
Issue 9
Pg. 2644-50
(Sep 2010)
ISSN: 1573-2568 [Electronic] United States |
PMID | 19960252
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Lipoproteins, HDL
- Lipoproteins, LDL
- Triglycerides
- Cholesterol
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Topics |
- Adult
- Atherosclerosis
(blood, etiology, pathology)
- Biomarkers
(blood)
- Biopsy
- Cardiovascular Diseases
(blood, etiology, pathology)
- Chi-Square Distribution
- Cholesterol
(blood)
- Cross-Sectional Studies
- Fatty Liver
(blood, complications, pathology)
- Female
- Hepatitis
(blood, etiology, pathology)
- Humans
- Lipoproteins, HDL
(blood)
- Lipoproteins, LDL
(blood)
- Liver
(pathology)
- Male
- Middle Aged
- Ohio
- Risk Assessment
- Risk Factors
- Severity of Illness Index
- Triglycerides
(blood)
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