Cutaneous vasculitis associated with interferon beta-1b treatment for multiple sclerosis.

Abstract

We report a 38-year-old woman with relapsing-remitting multiple sclerosis, treated with subcutaneous injections of interferon beta (IFN-beta)-1b every other day. Disseminated cutaneous lesions were observed after 3 injections. These symptoms reappeared after drug readministration. The histopathological examination of the skin specimens confirmed nonspecific cutaneous lymphocytic vasculitis. The patient's outcome was favorable after corticosteroid placement and discontinuing IFN-beta therapy. Isolated lymphocytic cutaneous vasculitis linked to IFN-beta-1b therapy is suspected as a new association.

• Authors: Jarmila Szilasiová, Zuzana Gdovinová, Jagienka Jautová, Janette Baloghová, Marta Ficová, Peter Bohus
• Journal: Clinical neuropharmacology (Clin Neuropharmacol) 2009 Sep-Oct Vol. 32 Issue 5 Pg. 301-3 ISSN: 1537-162X [Electronic] United States
• PMID: 19820436 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interferon beta-1b
• Interferon-beta

Topics

• Adult
• Female
• Humans
• Interferon beta-1b
• Interferon-beta (adverse effects)
• Multiple Sclerosis (drug therapy, pathology)
• Treatment Outcome
• Vasculitis, Leukocytoclastic, Cutaneous (chemically induced, diagnosis, pathology)