Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity.

Abstract

OBJECTIVE:

To determine the influence of allergic rhinitis (AR) on the expression of matrix metalloproteinase (MMP)-9, MMP-2, and tissue inhibitor-1 of metalloproteinase (TIMP-1) in nasal polyposis.

STUDY DESIGN:

A case-control study.

SETTING:

A tertiary referral center.

SUBJECTS AND METHODS:

The expression of MMP-9, MMP-2, and TIMP-1 was investigated in the nasal polyp tissue (NP) and maxillary sinus mucosa (MM) samples from 20 AR patients and 20 nonallergic patients undergoing endoscopic sinus surgery. Trichrome, periodic acid-Schiff, and hematoxylin-eosin staining were also performed and those expression levels were compared.

RESULTS:

Infiltration of eosinophils was shown more intensely in NP rather than in MM, especially in the presence of AR. In the NP of AR patients, increased expression of MMP-9, MMP-2, and TIMP-1 was observed more prominently than in that of the control group. In case of MM, however, there was no significant difference between AR patients and the control group.

CONCLUSION:

The presence of AR may enhance the expression of MMP-9, MMP-2, and TIMP-1 associated with airway remodeling in nasal polyposis.

• Authors: Hyun-Woo Shin, Doo Hee Han, Yune Sung Lim, Hye Jung Kim, Dong-Young Kim, Chul Hee Lee, Yang-Gi Min, Chae-Seo Rhee
• Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 141 Issue 4 Pg. 442-7 (Oct 2009) ISSN: 1097-6817 [Electronic] England
• PMID: 19786210 (Publication Type: Journal Article)

Chemical References

• Tissue Inhibitor of Metalloproteinase-1
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Adolescent
• Adult
• Aged
• Humans
• Immunohistochemistry
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Maxillary Sinus
• Middle Aged
• Nasal Mucosa (enzymology, metabolism, pathology)
• Nasal Polyps (complications, enzymology, pathology)
• Rhinitis, Allergic, Perennial (complications)
• Rhinitis, Allergic, Seasonal (complications)
• Tissue Inhibitor of Metalloproteinase-1 (metabolism)
• Young Adult