Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients.

Abstract

BACKGROUND:

Several investigations have reported associations the serotonin 1A (5-HT1A) receptor to schizophrenia and psychotic disorders, making 5-HT1A receptor gene (HTR1A) an adequate candidate gene for the pathophysiology of schizophrenia and methamphetamine (METH)-induced psychosis. Huang and colleagues reported that rs6295 in HTR1A was associated with schizophrenia. The symptoms of methamphetamine (METH)-induced psychosis are similar to those of paranoid type schizophrenia. It may indicate that METH-induced psychosis and schizophrenia have common susceptibility genes. In support of this hypothesis, we reported that the V-act murine thymoma viral oncogene homologue 1 (AKT1) gene was associated with METH-induced psychosis and schizophrenia in the Japanese population. Furthermore, we conducted an analysis of the association of HTR1A with METH-induced psychosis.

METHOD:

Using one functional SNP (rs6295) and one tagging SNP (rs878567), we conducted a genetic association analysis of case-control samples (197 METH-induced psychosis patients and 337 controls) in the Japanese population. The age and sex of the control subjects did not differ from those of the methamphetamine dependence patients.

RESULTS:

Rs878567 was associated with METH-induced psychosis patients in the allele/genotype-wise analysis. Moreover, this significance remained after Bonferroni correction. In addition, we detected an association between rs6295 and rs878567 in HTR1A and METH-induced psychosis patients in the haplotype-wise analysis. Although we detected an association between rs6295 and METH-induced psychosis patients, this significance disappeared after Bonferroni correction.

CONCLUSION:

HTR1A may play an important role in the pathophysiology of METH-induced psychosis in the Japanese population. However, because we did not perform a mutation scan of HTR1A, a replication study using a larger sample may be required for conclusive results.

• Authors: Taro Kishi, Tomoko Tsunoka, Masashi Ikeda, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Takenori Okumura, Yoshio Yamanouchi, Yoko Kinoshita, Hiroshi Ujike, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Nakao Iwata
• Journal: Neuropharmacology (Neuropharmacology) Vol. 58 Issue 2 Pg. 452-6 (Feb 2010) ISSN: 1873-7064 [Electronic] England
• PMID: 19747927 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: 2009. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Central Nervous System Stimulants
• Receptor, Serotonin, 5-HT1A
• Methamphetamine

Topics

• Adult
• Amphetamine-Related Disorders (genetics)
• Asian People (genetics)
• Case-Control Studies
• Central Nervous System Stimulants (toxicity)
• Female
• Genetic Association Studies
• Genotype
• Humans
• Japan
• Linkage Disequilibrium
• Male
• Methamphetamine (toxicity)
• Polymorphism, Single Nucleotide
• Psychoses, Substance-Induced (genetics)
• Receptor, Serotonin, 5-HT1A (genetics)
• Sequence Analysis, DNA