Abstract | BACKGROUND:
Premedication with beta-2 agonists (e.g. salbutamol) is effective in preventing increases in total respiratory resistance and in decreasing the incidence of perioperative bronchospasm in asthmatic children. Because children with recent respiratory tract infection (RTI) exhibit bronchial hyperreactivity similar to that observed in asthmatic children, the use of salbutamol in children with RTI has become popular among pediatric anesthetists for the prevention of perioperative respiratory adverse events (PRAE). In a prospective observational study, we therefore assessed the usefulness of salbutamol premedication on the occurrence of PRAE. METHODS: RESULTS: Children with a recent RTI who received salbutamol demonstrated a significantly reduced incidence of perioperative bronchospasm (5.5% vs 11%, P = 0.0270) and severe coughing (5.5% vs 11.5%, P = 0.0314) compared with children who had an RTI but did not receive salbutamol. However, healthy children presented with the lowest rate ( bronchospasm 1.5%, severe coughing 4.5%) of respiratory complications compared with children with a recent RTI independent whether or not they received salbutamol preoperatively. CONCLUSIONS:
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Authors | Britta S von Ungern-Sternberg, Walid Habre, Thomas O Erb, Mairead Heaney |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 19
Issue 11
Pg. 1064-9
(Nov 2009)
ISSN: 1460-9592 [Electronic] France |
PMID | 19694973
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Agonists
- Albuterol
- Oxygen
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Topics |
- Adolescent
- Adrenergic beta-Agonists
(administration & dosage)
- Albuterol
(administration & dosage)
- Bronchial Spasm
(etiology, prevention & control)
- Child
- Child, Preschool
- Cough
(etiology, prevention & control)
- Female
- Humans
- Infant
- Infant, Newborn
- Intraoperative Complications
(prevention & control)
- Laryngismus
(etiology, prevention & control)
- Male
- Medical Audit
- Oxygen
(blood)
- Preanesthetic Medication
(methods)
- Prospective Studies
- Respiratory Tract Infections
(complications)
- Treatment Outcome
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