Single low-dose red light is as efficacious as methyl-aminolevulinate--photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring.
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| Abstract |
This controlled study investigated single low-dose red light photodynamic therapy and methyl-aminolevulinate (MAL) for treatment of moderate to severe facial acne in 19 patients. The right cheek was treated with MAL (160 mg/g) for 3 h prior to illumination. The left cheek received red light only. Both cheeks were illuminated with narrow-band red light (635 nm) at a light dose of 15 J/cm2. The global severity of acne was assessed at baseline and at follow-up, 10 and 20 weeks after treatment. Fluorescence images, clinical photographs and skin surface biopsies were obtained. Both MAL-photodynamic therapy and control areas showed a significant decrease in acne score at follow-up; no significant difference was found compared with control. MAL-photodynamic therapy was associated with adverse effects such as erythema and stinging. Fluorescence images revealed poor selectivity of MAL-induced fluorescence to the acne lesions, suggesting a general photoablating mechanism rather than selective destruction of sebaceous glands. No significant reduction in Propionibacterium acnes or sebum excretion was found.
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| Authors | Camilla Hörfelt, Bo Stenquist, Christina B Halldin, Marica B Ericson, Ann-Marie Wennberg |
| Journal | Acta dermato-venereologica (Acta Derm Venereol) Vol. 89 Issue 4 Pg. 372-8 ( 2009) ISSN: 1651-2057 [Electronic] Sweden |
| PMID | 19688149 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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