Abstract | BACKGROUND:
Ostene, a synthetic water-soluble bone hemostatic agent, is commercially available. In the current study, we evaluated the systemic and local effects of this copolymer in a rabbit model. METHODS: Eighteen rabbits underwent creation of a bony defect at right iliac crest. These rabbits were then evenly divided into 3 groups. In group 1, the defect surfaces were treated with bone wax; in group 2, the defect surfaces were treated with Ostene; in group 3, the defect surfaces were not treated with anything. Then, the animals underwent blood examinations, including WBC count, CRP, and ESR at 0, 1, 3, and 6 weeks, and were killed at 6 weeks for histologic examination. Another 6 rabbits (group 4) underwent the same surgical treatment of group 2 animals but had blood examinations of BUN and creatinine. RESULTS: The blood examinations showed that the WBC count, CRP, and ESR of all the animals in the first 3 groups were within normal limits in the postoperative periods. Microscopic examinations demonstrated residual bone wax and fibrotic tissue at the defect surfaces in group 1 animals. However, there was no Ostene at the defect surfaces in group 2 animals. The groups 2 and 3 animals showed no fibrotic tissue at the defect surfaces. The group 4 animals showed normal serum levels of BUN and creatinine in the postoperative periods. CONCLUSION:
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Authors | Tao-Chen Lee, Nyuk-Kong Chang, Feng-Wen Su, Yu-Lin Yang, Thung-Ming Su, Yu-Jun Lin, Wan-Ching Lin, Hsiu-Yu Huang |
Journal | Surgical neurology
(Surg Neurol)
Vol. 72 Suppl 2
Pg. S75-9; discussion S79
(Dec 2009)
ISSN: 1879-3339 [Electronic] United States |
PMID | 19665194
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Bone Substitutes
- Drug Combinations
- Ostene
- Palmitates
- Polymers
- Waxes
- Poloxamer
- bone wax
- C-Reactive Protein
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Topics |
- Animals
- Biomarkers
(analysis, metabolism)
- Bone Diseases
(surgery)
- Bone Substitutes
(chemistry, toxicity)
- C-Reactive Protein
(analysis, metabolism)
- Disease Models, Animal
- Drug Combinations
- Inflammation
(chemically induced, physiopathology)
- Kidney Diseases
(chemically induced, physiopathology)
- Leukocyte Count
- Male
- Palmitates
(therapeutic use)
- Poloxamer
(chemistry, toxicity)
- Polymers
(chemistry, toxicity)
- Rabbits
- Plastic Surgery Procedures
(methods)
- Waxes
(therapeutic use)
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