In vivo antibacterial activity of vertilmicin, a new aminoglycoside antibiotic.

Abstract

Vertilmicin is a novel aminoglycoside antibiotic with potent activity against gram-negative and -positive bacteria in vitro. In this study, we further evaluated the efficacy of vertilmicin in vivo in systemic and local infection animal models. We demonstrated that vertilmicin had relatively high and broad-spectrum activities against mouse systemic infections caused by Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecalis. The 50% effective doses of subcutaneously administered vertilmicin were 0.63 to 0.82 mg/kg, 0.18 to 0.29 mg/kg, 0.25 to 0.99 mg/kg, and 4.35 to 7.11 mg/kg against E. coli, K. pneumoniae, S. aureus, and E. faecalis infections, respectively. The therapeutic efficacy of vertilmicin was generally similar to that of netimicin, better than that of gentamicin in all the isolates tested, and better than that of verdamicin against E. coli 9612 and E. faecalis HH22 infections. The therapeutic efficacy of vertilmicin was further confirmed in local infection models of rabbit skin burn infection and mouse ascending urinary tract infection.

• Authors: Xue-Fu You, Cong-Ran Li, Xin-Yi Yang, Min Yuan, Wei-Xin Zhang, Ren-Hui Lou, Yue-Ming Wang, Guo-Qing Li, Hui-Zhen Chen, Dan-Qing Song, Cheng-Hang Sun, Shan Cen, Li-Yan Yu, Li-Xun Zhao, Jian-Dong Jiang
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 10 Pg. 4525-8 (Oct 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 19635958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aminoglycosides
• Anti-Bacterial Agents
• verdamicin
• Netilmicin

Topics

• Aminoglycosides (pharmacology)
• Animals
• Anti-Bacterial Agents (pharmacology)
• Burns (microbiology)
• Enterococcus faecalis (drug effects)
• Escherichia coli (drug effects)
• Female
• Klebsiella pneumoniae (drug effects)
• Male
• Mice
• Microbial Sensitivity Tests
• Netilmicin (pharmacology)
• Rabbits
• Skin Diseases (drug therapy, microbiology)
• Staphylococcus aureus (drug effects)
• Urinary Tract Infections (drug therapy, microbiology)