The tissue-type plasminogen activator story.

Abstract

Milestones in the development of tissue-type plasminogen activator (t-PA) as a fibrin-specific thrombolytic agent include: purification of human t-PA from the culture fluid of the Bowes melanoma cell line, elucidation of the molecular basis of fibrin-specific plasminogen activation, first experimental animal models of thrombosis, first patient (renal allograft) treated with melanoma t-PA, pilot studies in patients with acute myocardial infarction, cloning and expression of recombinant t-PA providing sufficient amounts for large scale clinical use, and demonstration of its therapeutic benefit in large multicenter clinical trials.

• Authors: D Collen, H R Lijnen
• Journal: Arteriosclerosis, thrombosis, and vascular biology (Arterioscler Thromb Vasc Biol) Vol. 29 Issue 8 Pg. 1151-5 (Aug 2009) ISSN: 1524-4636 [Electronic] United States
• PMID: 19605778 (Publication Type: Historical Article, Journal Article)

Chemical References

• Fibrinolytic Agents
• Recombinant Proteins
• Tissue Plasminogen Activator

Topics

• Animals
• Fibrinolytic Agents (history, therapeutic use)
• History, 20th Century
• Humans
• Recombinant Proteins (chemical synthesis, history, therapeutic use)
• Thrombolytic Therapy (history, methods)
• Thrombosis (blood, drug therapy, history)
• Tissue Plasminogen Activator (chemical synthesis, history, therapeutic use)