Chromosome 9p21 polymorphism is associated with myocardial infarction but not with clinical outcome in Han Chinese.

Abstract

BACKGROUND:

rs1333049 polymorphism on chromosome 9p21 has been shown to affect susceptibility to coronary artery disease (CAD) in Caucasians. This study examined the association of rs1333049 with myocardial infarction (MI), angiographic severity of CAD and clinical outcome after a first acute MI in Han Chinese.

METHODS:

rs1333049 polymorphism was genotyped in 520 patients with a first acute MI and in 560 controls. The number of angiographically documented diseased coronary arteries (luminal diameter stenosis > or = 50%), echocardiographic left ventricular ejection fraction (LVEF), and major adverse cardiac events (MACE) during follow-up (mean, 29+/-15 months) were recorded.

RESULTS:

Patients with MI had higher frequencies of the CC genotype (30.0% vs. 20.7%) or C allele (55.5% vs. 46.2%) compared with controls (all p<0.01). rs1333049 polymorphism was strongly associated with MI [odds ratio (OR) 1.48, 95% confidence interval (CI) 1.22-1.79] after adjusting for traditional risk factors. Although longer hospitalization stay was observed in patients with the rs1333049-C allele, this polymorphism was not related to angiographic severity of CAD, LVEF, and occurrence of MACE after MI.

CONCLUSIONS:

This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese.

• Authors: Wen Hui Peng, Lin Lu, Qi Zhang, Rui Yan Zhang, Ling Jie Wang, Xiao Xiang Yan, Qiu Jing Chen, Wei Feng Shen
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 47 Issue 8 Pg. 917-22 ( 2009) ISSN: 1437-4331 [Electronic] Germany
• PMID: 19548844 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Alleles
• Asian People (genetics)
• China (epidemiology)
• Chromosomes, Human, Pair 9 (genetics)
• Female
• Gene Frequency (genetics)
• Genetic Predisposition to Disease
• Genotype
• Humans
• Kaplan-Meier Estimate
• Linkage Disequilibrium (genetics)
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Myocardial Infarction (epidemiology, genetics, mortality)
• Polymorphism, Single Nucleotide