Proteomics in extracorporeal blood purification and peritoneal dialysis.

Abstract

Extracorporeal blood purification and peritoneal dialysis are widely used in renal replacement therapy for patients with end-stage renal disease (ESRD) and acute kidney injury (AKI). Additionally, extracorporeal blood purification can be used also for treatment of non-renal disorders to remove endogenous or exogenous toxins from the blood circulation. Efforts have been made to characterize these toxins removed by diffusion (dialysis), convection (ultrafiltration), and/or adsorption (toxins are adsorbed onto the dialysis membrane and are thus removed) using different types of dialysis membrane. This review summarizes important findings obtained from recent proteomic studies applied to extracorporeal blood purification and peritoneal dialysis in settings of ESRD, AKI and hepatic failure.

• Authors: Visith Thongboonkerd
• Journal: Journal of proteomics (J Proteomics) Vol. 73 Issue 3 Pg. 521-6 (Jan 03 2010) ISSN: 1876-7737 [Electronic] Netherlands
• PMID: 19527805 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: (c) 2009 Elsevier B.V. All rights reserved.

Chemical References

• Blood Proteins
• Toxins, Biological

Topics

• Acute Kidney Injury (blood, metabolism)
• Blood Component Removal (methods)
• Blood Proteins (analysis, isolation & purification, metabolism)
• Extracorporeal Circulation (methods)
• Humans
• Kidney Failure, Chronic (blood, metabolism)
• Liver Failure (blood, metabolism)
• Models, Biological
• Peritoneal Dialysis (methods)
• Proteomics (methods)
• Renal Dialysis (methods)
• Toxins, Biological (analysis, blood, isolation & purification)