[The significance of metalloproteinases and their inhibitors in gastric cancer].

Abstract

A crucial step in tumor development and metastasis is degradation of the extracellular matrix (ECM). Matrix metalloproteinases (MMPs) are enzymes able to degrade type IV collagen. The proteolytic activity of MMPs is regulated by tissue inhibitors of metalloproteinases (TIMPs). It has been shown that MMP and TIMP expression and concentration correlated with clinicopathological features of tumor, such as tumor stage, depth of tumor invasion, the presence of lymph node and distant metastases. Some clinical investigations have suggested the usefulness of MMP sand TIMPs as prognostic factors for the survival of gastric cancer patients.

• Authors: Marta Lukaszewicz-Zajac, Barbara Mroczko, Maciej Szmitkowski
• Journal: Postepy higieny i medycyny doswiadczalnej (Online) (Postepy Hig Med Dosw (Online)) Vol. 63 Pg. 258-65 (Jun 05 2009) ISSN: 1732-2693 [Electronic] Poland
• Vernacular Title: Znaczenie metaloproteinaz oraz ich inhibitorów w raku zoładka.
• PMID: 19502687 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Tissue Inhibitor of Metalloproteinases
• Metalloproteases

Topics

• Humans
• Metalloproteases (metabolism)
• Neoplasm Invasiveness
• Neoplasm Metastasis (pathology)
• Neoplasm Staging
• Stomach Neoplasms (enzymology, pathology)
• Tissue Inhibitor of Metalloproteinases (metabolism)