HLA-B*15 subtypes in Burmese population by sequence-based typing.

Abstract

Human leukocyte antigen (HLA)-B*15 encompasses an increasing number of subtypes of more than 150. Frequency studies and a strong genetic association between HLA subtypes and susceptibility to drug hypersensitivity have been reported in different ethnic populations. To identify HLA-B*15 subtypes in Burmese using sequence-based typing (SBT) method, we selected 65 HLA-B*15-positive samples from 170 unrelated healthy Burmese who were genotyped HLA-B* by polymerase chain reaction with the sequence-specific primer method. The frequency of HLA-B*15 in Burmese was found to be 38.2%. By the SBT method, results showed 10 alleles of HLA-B*15 subtypes. Four common alleles, B*1502 (45.2%), B*1532 (16.4%), B*1525 (12.3%), and B*1501 (8.2%), were found in 82.1% of HLA-B*15-positive Burmese. Whereas the B*1501 was the highest in the Caucasians, Koreans, and Japanese, the highest frequency of HLA-B*15 alleles in Burmese was B*1502 (45.2%) that is similar to the frequency found in northeastern Thais and Vietnamese. This study is the first report of HLA-B*15 subtypes in Burmese. These results will provide the basic data in the further study in transplantations, genetic association with diseases, and drug hypersensitivity.

• Authors: C Kongmaroeng, A Romphruk, R Ruangwerayut, C Paupairoj, C Leelayuwat, H Inoko, A Romphruk
• Journal: Tissue antigens (Tissue Antigens) Vol. 74 Issue 2 Pg. 164-7 (Aug 2009) ISSN: 1399-0039 [Electronic] England
• PMID: 19497038 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-B Antigens
• HLA-B15 Antigen

Topics

• Gene Frequency
• Genotype
• HLA-B Antigens (analysis, classification, genetics)
• HLA-B15 Antigen
• Histocompatibility Testing (methods)
• Humans
• Myanmar (ethnology)
• Polymorphism, Genetic
• Sequence Analysis, DNA
• Thailand