Abstract | BACKGROUND: OBJECTIVE: We characterized the chronic oral toxicity and carcinogenicity of Cr(VI) in rodents. METHODS: RESULTS:
Cr(VI) exposure resulted in increased incidences of rare neoplasms of the squamous epithelium that lines the oral cavity (oral mucosa and tongue) in male and female rats, and of the epithelium lining the small intestine in male and female mice. Cr(VI) exposure did not affect survival but resulted in reduced mean body weights and water consumption, due at least in part to poor palatability of the dosed water. Cr(VI) exposure resulted in transient microcytic hypochromic anemia in rats and microcytosis in mice. Nonneoplastic lesions included diffuse epithelial hyperplasia in the duodenum and jejunum of mice and histiocytic cell infiltration in the duodenum, liver, and mesenteric and pancreatic lymph nodes of rats and mice. CONCLUSIONS:
Cr(VI) was carcinogenic after administration in drinking water to male and female rats and mice.
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Authors | Matthew D Stout, Ronald A Herbert, Grace E Kissling, Bradley J Collins, Gregory S Travlos, Kristine L Witt, Ronald L Melnick, Kamal M Abdo, David E Malarkey, Michelle J Hooth |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 117
Issue 5
Pg. 716-22
(May 2009)
ISSN: 1552-9924 [Electronic] United States |
PMID | 19479012
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Carcinogens
- Chromium
- chromium hexavalent ion
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Topics |
- Administration, Oral
- Animals
- Carcinogens
(administration & dosage, toxicity)
- Carcinoma, Squamous Cell
(chemically induced, pathology)
- Chromium
(administration & dosage, toxicity)
- Female
- Male
- Mice
- Mouth
(drug effects, pathology)
- Mouth Neoplasms
(chemically induced, pathology)
- Rats
- Rats, Inbred F344
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