Abstract | OBJECTIVE: STUDY DESIGN: Using a cross-sectional study design, hs-CRP, IL-6, TNF-alpha, homocysteine and vitamin B12 were measured in the third trimester of pregnancy from normotensive healthy women with uncomplicated pregnancies (n = 62), mild (n = 61) and severe (n = 60) preeclamptic patients. RESULTS: There were statistically significant differences between three groups for hs-CRP (p = 0.012), TNF- alpha (p = 0.046), IL-6 (p = 0.015), homocysteine (p < 0.001) and fetal birth weight (p < 0.001). Fetal birth weights in mild (2477 +/- 746) and severe (2435 +/- 768) preeclamptic patients were significantly lower than controls (3485 +/- 365) (p < 0.001). No significant difference was found between the three groups for folic acid (p = 0.066) and vitamin B12 (p = 0.286). Bonferroni adjusted multiple comparison test showed that the statistical differences with respect to TNF-alpha, IL-6 and homocysteine were mainly created by control and severe preeclampsia groups. Hs-CRP levels still remained higher in severe preeclampsia patients than mild preeclampsia and normotensive patients except for overweight patients in the previous two groups after Bonferroni post hoc adjustment test. CONCLUSION:
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Authors | Melih A Guven, Ayhan Coskun, Ibrahim Egemen Ertas, Murat Aral, Beyazit Zencirci, Hafize Oksuz |
Journal | Hypertension in pregnancy
(Hypertens Pregnancy)
Vol. 28
Issue 2
Pg. 190-200
(May 2009)
ISSN: 1525-6065 [Electronic] England |
PMID | 19437229
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Interleukin-6
- Tumor Necrosis Factor-alpha
- Homocysteine
- C-Reactive Protein
- Folic Acid
- Vitamin B 12
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Topics |
- Adult
- Biomarkers
(blood)
- Birth Weight
- C-Reactive Protein
(metabolism)
- Cross-Sectional Studies
- Female
- Folic Acid
(metabolism)
- Homocysteine
(blood)
- Humans
- Infant, Low Birth Weight
- Infant, Newborn
- Interleukin-6
(blood)
- Pre-Eclampsia
(blood, physiopathology)
- Pregnancy
- Pregnancy Trimester, Third
- Tumor Necrosis Factor-alpha
(blood)
- Vitamin B 12
(blood)
- Young Adult
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