Abstract | BACKGROUND: METHODS: Adult male Sprague-Dawley rats were anesthetized with halothane to maintain normocapnia and normoxia. Rats received subcutaneous injection of saline 1 ml/kg, lidocaine 10 mg/kg, dexmedetomidine 3 microg/kg, or lidocaine 10 mg/kg plus dexmedetomidine 3 microg/kg. Thirty minutes after the drug injection, forebrain ischemia was induced by hemorrhagic hypotension and occlusion of the bilateral carotid arteries, and was confirmed by isoelectric EEG. At the end of 10-min ischemia, rats were reperfused. The same dose of drugs was administered 3, 24, and 48 h after ischemia. Neurological examination was done at 1, 2, and 7 days after ischemia. Seven days after ischemia, the brain was stained with hematoxylin and eosin. We counted ischemic cells in the CA1 hippocampal region, striatum, and cerebral cortex. We also measured extracellular glutamate and norepinephrine concentration in hippocampal CA1 in the four groups. RESULTS: CONCLUSIONS:
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Authors | T Goyagi, T Nishikawa, Y Tobe, Y Masaki |
Journal | Acta anaesthesiologica Scandinavica
(Acta Anaesthesiol Scand)
Vol. 53
Issue 9
Pg. 1176-83
(Oct 2009)
ISSN: 1399-6576 [Electronic] England |
PMID | 19388884
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Local
- Drug Combinations
- Hypnotics and Sedatives
- Neuroprotective Agents
- Neurotransmitter Agents
- Glutamic Acid
- Dexmedetomidine
- Lidocaine
- Norepinephrine
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Topics |
- Anesthetics, Local
(therapeutic use)
- Animals
- Blood Gas Analysis
- Blood Pressure
(drug effects)
- Body Temperature
(drug effects)
- Brain Chemistry
(drug effects)
- Cerebrovascular Circulation
(drug effects)
- Dexmedetomidine
(therapeutic use)
- Drug Combinations
- Glutamic Acid
(metabolism)
- Heart Rate
(drug effects)
- Hippocampus
(drug effects, metabolism)
- Hypnotics and Sedatives
(therapeutic use)
- Ischemic Attack, Transient
(drug therapy)
- Lidocaine
(therapeutic use)
- Male
- Microdialysis
- Neuroprotective Agents
- Neurotransmitter Agents
(metabolism)
- Norepinephrine
(metabolism)
- Prosencephalon
(blood supply, drug effects)
- Rats
- Rats, Sprague-Dawley
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