Abstract | BACKGROUND AND PURPOSE: MATERIALS AND METHODS: Retrospective assessment of 151 patients with PRES was performed, and 23 patients were identified who had intracranial hemorrhage at toxicity. Hemorrhage types were identified and tabulated, including minute focal hemorrhages (<5 mm), sulcal subarachnoid hemorrhage, and focal hematoma. Clinical features of hemorrhage and nonhemorrhage PRES groups were evaluated, including toxicity blood pressure, coagulation profile/platelet counts, coagulation-altering medication, and clinical conditions associated with PRES. Toxicity mean arterial pressure (MAP) groups were defined as normal (<106 mm Hg), mildly hypertensive (106-116 mm Hg), or severely hypertensive (>116 mm Hg). RESULTS: The overall incidence of hemorrhage was 15.2%, with borderline statistical significance noted between the observed clinical associations (P = .07). Hemorrhage was significantly more common (P = .02) after allogeneic bone marrow transplantation (allo-BMT) than after solid- organ transplantation. The 3 hemorrhage types were noted with equal frequency. A single hemorrhage type was found in 16 patients, with multiple types noted in 7. Patients undergoing therapeutic anticoagulation were statistically more likely to develop hemorrhage (P = .04). No difference in hemorrhage incidence was found among the 3 blood pressure subgroups (range, 14.9%-15.9%). CONCLUSIONS:
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Authors | H M Hefzy, W S Bartynski, J F Boardman, D Lacomis |
Journal | AJNR. American journal of neuroradiology
(AJNR Am J Neuroradiol)
Vol. 30
Issue 7
Pg. 1371-9
(Aug 2009)
ISSN: 1936-959X [Electronic] United States |
PMID | 19386731
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Cerebral Hemorrhage
(diagnosis, epidemiology)
- Comorbidity
- Female
- Humans
- Incidence
- Magnetic Resonance Imaging
(statistics & numerical data)
- Male
- Middle Aged
- Pennsylvania
(epidemiology)
- Posterior Leukoencephalopathy Syndrome
(diagnosis, epidemiology)
- Risk Assessment
(methods)
- Risk Factors
- Tomography, X-Ray Computed
(statistics & numerical data)
- Young Adult
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